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The neuroprotective potential of flavonoids: a multiplicity of effects

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Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls

Neurological Function Score (Modified Longa System) Neurological deficits were evaluated 1 hour after ET-1 injection using the modified Longa scoring system: 0: No observable neurological deficit (excluded from analysis) 1: Failure to fully extend the left forepaw 2: Consistent circling to the left 3: Falling or leaning to the left side when ambulating 4: No spontaneous movement (severe infarction) Animals scoring between 1 and 3 were considered to have moderate ischemic deficits and were included in further analyses

The fully conserved KTxxxW domain is an intracellular domain at the C-terminal side of FZD proteins and interacts with the protein-95/discs-large/zona occludens-1 (PDZ) domains of DvL proteins