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Furthermore, its cytoprotective actions, particularly in gastric mucosa, have been a long-standing area of research, suggesting a broad protective capacity against diverse cellular stressors

[DOI] [PubMed] [Google Scholar] Kempermann G., Gage F.H., Aigner L., Song H., Curtis M.A., Thuret S., Kuhn H.G., Jessberger S., Frankland P.W., Cameron H.A

Metformin primarily targets IR by enhancing insulin sensitivity, reducing hepatic gluconeogenesis, and increasing muscle glucose uptake (Xing et al., 2021)

High NNMT expression is significantly associated with unfavorable prognosis

For example, knowledge of the endogenous physiological actions of NO in the nervous system raises the possibility of manipulating the NO system for therapeutic benefit (Calabrese et al