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In the brain, antibody binding has been observed in regions such as the basal ganglia, hippocampal formation, olfactory bulb, and cerebral cortex [45]

The mechanism of inhibition of CYPs expression may be due to the presence of a methylenedioxyphenyl (MDP) group in EDDs structures that exerted a high ability to bind to the heme group of cytochrome P 450 isozyme (CYP3A4) [46, 47]

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Gastrointest Endosc 63:1130 Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023

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