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A review published in 2024 by Sikiric and colleagues found that this peptide is highly stable in gastric environments (the acidity inside a living stomach) and summarized its broad range of investigated biological activities
Cartilage and joint repair models: Intraarticular injection of AOD9604 in a collagenase induced rabbit osteoarthritis model showed improved cartilage architecture and regeneration
Regarding neuroplasticity regulation, suppressed Notch/DNER signaling and dysregulated Wnt/AXIN1 pathway may compromise hippocampal neurogenesis [26, 53, 54], while disrupted NTRK2-BDNF signaling and impaired Nr-CAM-mediated cell adhesion could lead to decreased synaptophysin synthesis and dendritic complexity [55]
Diagnosis should include serum B12 levels interpreted in clinical context, full blood count, and where appropriate, intrinsic factor antibodies and parietal cell antibodies
