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Among the clotting time measures, mPT was the most sensitive to the effects of apixaban with a mean maximum increase from the baseline of approximately 226%229%, following administration of a 50 mg single dose, and exhibited a steeper concentrationresponse relationship than that for INR, which exhibited approximately a 50%64% increase at the 50 mg dose (Figures 3, S1, and S2 and Tables S1 and S2)

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By delivering these peptides directly to the nasal mucosa, this blend enables rapid absorption and bypasses the digestive system, potentially enhancing bioavailability and efficacy for laboratory purposes