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Aspirin and NSAID usage has been associated with gastrointestinal toxicity including bleeding ulcer (Singh 1998

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However, oral administration of KO reversed the downregulation of the HAS genes, restored hyaluronic acid content in the skin, prevented skin water loss, and enhanced the moisturizing effect of the skin in UVB-induced skin photoaging mice ( The commonality of KO and its ingredients in resisting skin aging is mainly to reduce the production of ROS