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Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway ( Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993

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Second, redness can be harder to see on deeper skin tones, so rosacea and vascular redness are often underrecognized in patients with skin of color, and they may show up more as warmth, sensitivity, or a dusky flush than as bright red