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Moreover, curcuminoids are proven by clinical and preclinical trials to act synergistically against diabetes via different mechanism of action 6,77

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doi: 10.3389/fpsyt.2025.1589663 Received 10 March 2025 Accepted 06 May 2025 Published 29 May 2025 Volume 16 - 2025 Edited by Paulo Santos, University of Porto, Portugal Reviewed by Martn Garca Juarez, Autonomous University of Nuevo Len, Mexico Gayane Vardanyan, Yerevan State Medical University, Armenia Updates Copyright 2025 Luan, Wang, Shi, Zhang, Wang, Zhou, Wu, Liu, Li, Zhang, Shao, Chen, Chu and Wei

Another glutaminase inhibitor, JHU-083, extensively inhibits Gln-metabolizing enzymes and increases the concentrations of Gln and glucose in the TME by inhibiting glycolysis, relieving the hypoxic state

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