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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

SRT2379, SRT1460, and other derivative molecules SRT2379, SRT1460, and other structurally refined SIRT1 activators have shown metabolic benefits in models of diabetes, cardiovascular, and neurodegenerative diseases

On DIV12 the neurons were fixed (4% paraformaldehyde, 3% sucrose, 60 raM PIPES, 25 mM HEPES, 5 mM EGTA, 1 niM MgCl 2 , pH 7.4) for 20 min at room temperature and mounted

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doi: 10.1038/414813a