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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

There is a lack of long-term data beyond 23 months, and large-scale, randomized controlled trials are limited, according to Anetta Reszko, MD, a board-certified dermatologist and dermatologic surgeon, a clinical assistant professor of dermatology at Weill Cornell Medical College

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That said, no regulatory body endorses using expired medication

doi: 10.3390/life14111455 147 TohyamaCHondaY