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Deficiency of Glucose-6-Phosphate Dehydrogenase Is Frequent in Certain Areas & Is an Important Cause of Hemolytic Anemia NADPH , produced in the reaction catalyzed by the X-linked glucose-6-phosphate dehydrogenase (Table 52-5, reaction 9) in the pentose phosphate pathway (Chapter 21), plays a key role in supplying reducing equivalents in the red cell and in other cells such as the hepatocyte