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NKF 2013b)

Puerarin inhibits EMT induced by oxaliplatin via targeting carbonic anhydrase XII

Duration guided by mechanism timeline: Acute healing mechanisms (Thymosin Beta-4 wound closure) show effects within days to weeks, treatment courses 4-8 weeks typical

For example, metformin, a firstline agent in PCOS for insulin resistance, has been shown in patients with type 2 diabetes to blunt NET formation: in vitro, metformin prevented chromatin decondensation and DNA release and in vivo reduced circulating NET biomarkers (e.g., dsDNA, citrullinated histone H3) independent of glucoselowering effects [93]

40 , 201218.e9 (2022)