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These changes included improvements in body weight, insulin resistance, triglycerides, hs-CRP, leptin (an appetite-regulating hormone, high levels of which are often associated with obesity), HDL-cholesterol, and adiponectin

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In addition, G6PD-associated genes were demonstrated to be potentially involved in regulating focal adhesion, the MAPK, Jak-STAT, p53, long-term depression and apoptosis signaling pathways

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[98,102] In another clinical trial, a dosage of 100 mg/week of LJP-394 significantly reduced anti-dsDNA antibody levels but did not significantly prolong the time to renal flare compared to placebo