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Mechanisms of action of currently used antiseizure drugs

Aging and disease

Although not inherently toxic, extended treatment with ASMswhich is common for patients suffering from a chronic disease like epilepsycan lead to the production and accumulation of toxic secondary metabolites inside the cells, leading to side effects like allergic reactions, cell death and organ damage in severe cases 6

3.3.2 Cortisol Cortisol, a glucocorticoid hormone associated with stress, usually increases during fasting to maintain glucose homeostasis through mechanisms such as gluconeogenesis and increased fat utilization [44]