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TMAO potentially affects carbohydrate, TAG and cholesterol metabolism by influencing the total bile acid pool size through the reduction of bile acid production via the suppression of the crucial enzymes CYP1A1 and CYP27A1, as well as by restricting bile acid enterohepatic circulation through the repression of the organic anion transporter and the expression of the multidrug resistance protein family (Reference Song and Malhi24)

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Repeated temperature excursions cause cumulative damage that compounds with each occurrence

Key Points Signal transduction pathways that contribute to synaptic plasticity and to learning and memory processes are key mediators of neuroadaptations underlying the transition from moderate use of alcohol to excessive, uncontrolled alcohol seeking and drinking