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Keap-1 is rich in sulfur-rich cysteine residues [99] and is under oxidation-reduction (and alkylation) control via its highly reactive thiol groups

Researchers initially identified BPC-157 while analyzing human gastric secretions

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The ensuing oxidative stress activates NF-B signaling, stimulates neuroinflammatory glial responses, and promotes P2X purinoceptor 7 (P2X7R)-mediated inflammasome assembly, thereby establishing a self-perpetuating cycle of neurodegeneration (Lee and Hyun, 2023

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