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Patients with this condition cannot absorb B12 from food or oral supplements and require lifelong intramuscular replacement therapy

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It is unclear exactly how much vitamin B12 a person would need to take to lead to hypercobalaminemia

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The oral capsule format is of particular interest in this area, since the swallowed peptide is delivered directly into the gastrointestinal tract, where much of this research activity has historically been localised and where the compounds reported stability in gastric conditions is most relevant