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The contribution of CKD to global morbidity and mortality is increasing rapidly 4 , highlighting the urgency of finding new targets and treatments

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Glutathione, a powerful antioxidant composed of three amino acidsglycine, glutamic acid, and cysteineplays a vital role in neutralizing free radicals, detoxifying harmful chemicals, and supporting numerous chemical reactions in the body

Th1 cells instigate cellular immunity, crucial for combatting intracellular pathogens

Cell-type identification was carried out manually on clusters generated at Leiden resolution 1, using gene activity data and curated gene markers from literature 57