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Unlike morphine, long-term exposure to analgesic mitragynine, 7-hydroxymitragynine, paynantheine, and speciociliatine alkaloids does not contribute to antinociceptive tolerance of -opioid receptors

[ Links ] Venkatraman, V., Dimoka, A., Pavlou, P.A., Vo, K., Hampton, W., Bollinger, B

FOOTNOTES [1] See Answers to Questions Related to the Management Rules for Electronic Cigarettes and the National Standard on Electronic Cigarettes, STMA, April 15, 2022, available at:

Unlike cigarettes or vapes, nicotine pouches do not produce smoke or vapor

Additionally, full-spectrum extracts with high terpene concentrations can cause throat irritation due to the presence of volatile organic compounds