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The "fire" of inflammation is gradually dampened over the following weeks heel pain eases and most patients return to their normal activity with a short course of stretching

Interestingly, repeated OS can initiate and maintain elevated levels of IL-1, leading to a positive feedback loop between OS and neuroinflammatory [104]

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She says several companies, including her own, are developing small-molecule TREM2 agonists that can turn up the volume on microglia, but only where amyloid or another misfolded protein or target is found