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Microneedling creates transient microchannels that substantially increase peptide penetration past the stratum corneum

[DOI] [PubMed] [Google Scholar] [199].Zhao Q, Wang M, Xu D, Zhang Q, Liu W, Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A, Nature 518 (7537) (2015) 115119

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Early changes include synaptic loss, dendritic spine retraction, mitochondrial fragmentation, and alterations in gene expression, all of which contribute to neuronal dysfunction before irreversible cell death [39, 41, 43]