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One study demonstrated that upregulation of Nrf2-regulated genes was inhibited in insulin-treated cerebral endothelial cells after 6 h of high glucose exposure, suggesting that insulin treatment can prevent or reduce oxidative stress (Arcambal et al., 2019)

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Peer review Peer review information Communications Biology thanks Chao Mao and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

It is particularly praised for having minimal side effects compared to other GH secretagogues, as Ipamorelin does not appear to elevate stress-related hormones