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* Correspondence: Omid Akbari, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

Science 368(6487):eaaw5473 Ferreira AP, Cassago A, de Gonalves K et al (2013) Active glutaminase C self-assembles into a supratetrameric oligomer that can be disrupted by an allosteric inhibitor

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