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Additional information Competing interests The authors declare that they have no competing interests

PNC-27, a novel anticancer peptide, holds great promise in the treatment of cancer due to its unique mechanism of action and selective cytotoxicity towards cancer cells (Goldberg et al., 2010)

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Surgery: Some types of gastrointestinal surgery, particularly those that remove or bypass the part of the small intestine where B12 is absorbed, can lead to B12 deficiency

These results suggest that combination antibiotic and probiotic therapy may be more effective for SIBO eradication and symptom relief in systemic sclerosis than either treatment alone