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Patients with chronic medical conditions should be especially careful about starting supplements without advice

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What the clinical data say, in brief Barrier and texture: Nicotinamide improves barrier metrics, elasticity, and hydration in randomized controlled studies

Always consult your doctor before taking any supplements during pregnancy or while breastfeeding

Moreover, it plays an immune negative regulatory role in chronic hepatitis B virus (HBA) infection by preventing the formation of germinal centers (GCs), reducing the antiviral activity of GC-related immune cells and enhancing the function of immunosuppressive cells [227]