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Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis

And then when you push past that to an optimal threshold, you get the insulatory benefits of cancer reduction that testosterone appears to provide

What it does WELL: Consistently elevates IGF-1 in randomized controlled trials and restores GH secretion to young-adult levels Increases fat-free mass over weeks and months in two-year double-blind RCT data Improves nitrogen retention and protein balance Enhances REM sleep and total sleep duration an approximately 50% increase in stage IV sleep and 20% increase in REM versus placebo Stimulates appetite via central ghrelin signaling What gets ignored: Consistently worsens insulin sensitivity and raises fasting glucose in multiple human trials a repeatable and replicable finding Commonly causes edema and joint discomfort The ensuing appetite dysregulation often leads to unwanted fat gain (i.e

Fan P, Tyagi AK, Agboke FA, Mathur R, Pokharel N, Jordan VC

Brewer GJ, Torricelli JR