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TNF Inhibitor Therapy for Psoriatic Arthritis As the beneficial effects of tumor necrosis factor (TNF) inhibitor therapy in rheumatoid arthritis (RA) became clear in the late 1990s, it was only a matter of time before interest grew in testing these agents in psoriatic arthritis (PsA), a disease widely perceived to have similar manifestations and pathophysiology

In preclinical studies, BPC-157 is typically dosed at 200500 mcg/kg, TB-500 at 210 mg/kg, and GHK-Cu at 13 mg/kg, administered via subcutaneous injection, intravenous infusion, or direct tissue injection depending on study design

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Some apparent differences arose partly from changes in placebo groups

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