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[Google Scholar] Selkoe, D

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41,155 As previously mentioned, leptin may increase the expression of the 5-HT 2B receptor in astrocytes via the LepR/JAK2/STAT3 pathway, and fluoxetine may be more effective in increasing BDNF levels and alleviating depressive-like behaviors due to the leptin-mediated increase in 5-HT 2B receptor expression

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29 Without an accurate PD biomarker, tracking target engagement, monitoring disease progression, and optimizing patient stratification is nearly impossible