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This combination of gene regulation, ECM modulation, and anti-inflammatory signaling underscores the peptide's pleiotropic nature in laboratory investigations

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It is also hydrophilic, suggesting problems in transporting it across the BBB (unlike PBN) (Halliwell and Gutteridge, 2015)

In addition to its central function as an intracellular antioxidant, it serves as a significant cofactor for several antioxidant enzymesincluding glutathione peroxidase (GPx) and glutathione S-transferases (GSTs)that neutralize reactive oxygen species (ROS) and other electrophilic compounds (14)