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Disruption of cysteine uptake and collapse of intracellular GSH pool induces an inhibition of the detoxifying activity of GPx4 and excessive accumulation of oxidatively damaged lipids at the membrane, although it remains unclear if this solely affects the cell plasma membrane, or the effect also extends to organelle membranes

According to Yong et al

Activation of NRF2 prevents tissue damage under pathological conditions 59

doi: 10.1016/S03037207(01)003860 279 NohMYKimYSLeeKYLeeYJKimSHYuHJet al

Determination of BPA Quantity The chromatographic analysis revealed that the mean BPA concentration was the highest in the serum of NETs-positive group, with the value being over eightfold higher than that determined for the control group