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Antioxidant defense via Nrf2 pathway activation Oxidative stress, the accumulation of reactive oxygen species that damage cells, mitochondria, and DNA, is a foundational driver of accelerated aging

It is also a reserve supply for cysteine, which plays an important role in protein synthesis

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Algorithms such as Support Vector Machines (SVM) and Random Forest can extract actionable insights from high-dimensional biological data, enabling the identification of novel therapeutic targets with greater efficiency and precision [248]

Similar content being viewed by others Introduction Lactate has long been considered a metabolic byproduct of glycolysis, especially known for its accumulation in the tumor microenvironment (TME) due to the Warburg effect. However, this conventional view has been fundamentally challenged in recent years