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1 Introduction Mitochondria, as quintessential organelles in eukaryotic cells, serve dual roles as cellular energy suppliers and key regulators of calcium homeostasis, oxidative stress responses, and apoptotic signaling pathways (Kamer and Mootha, 2015

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The primary concern with hepatic impairment is a potential change in exposure to a drug that is extensively cleared by hepatic metabolism or biliary excretion via the liver, that could impact on the pharmacodynamic action or lead to adverse effects [19]

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