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Reported Mild Effects: Temporary injection site redness Slight drowsiness (when dosed in evening) Vivid dreams or altered sleep patterns Mild headaches during initial days Management Strategies: Rotate injection sites regularly Reduce dosage if effects seem excessive Maintain hydration throughout protocol Consider timing adjustments for sleep-related effects When to Modify or Discontinue Certain situations warrant protocol modifications or discontinuation

Moreover, mounting evidence has demonstrated the feasibility of several types of CPPs, including TAT-PTD, TCTP-PTD, polyarginine, and penetratin and analogs thereof (Table 1), in the transepithelial delivery through nasal and intestinal epithelium (Zhu et al., 2014