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Research suggests that iron homeostasis in synovial tissue is regulated by iron regulatory proteins, revealing a strong link between synovitis, synovial hyperplasia, and iron deposition (Nieuwenhuizen et al., 2013)

The practice of using probiotics in food products or as a supplement having a particular health benefit requires prior human experiments, such as randomized clinical trials, positive meta-analyzes, or a strong suggestion from observational research studies (Hill et al., 2014)