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IV infusion therapy is recommended only when the anticipated benefit outweighs potential risks and when a clear clinical rationale exists

Search strategy This systematic review adhered to the guidelines employed the PICO(S) approach (Patient or Population, Intervention, Control or Comparison, Out- come, and Study types)

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Glutamine supports immune cell metabolism, especially lymphocyte proliferation and macrophage function, which makes it a key component in parenteral and enteral nutrition formulations targeting immune function maintenance