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10.1021/tx3002675 38 KoenY

166,167 The pathophysiology of diabetic mononeuropathy includes ischemic mechanisms, such as the occlusion of the vasa nervorum leading to nerve infarction, metabolic factors, including hyperglycemia-induced oxidative stress, and the formation of advanced glycation end products, contributing to nerve damage

Results depended on the time of administration and the experimental model, suggesting that any response may be strongly context-dependent

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By 1997, Ng and colleagues had identified the C-terminal segment of human GH as the primary region governing fat metabolism, and created AOD 9604 by adding a tyrosine residue to the fragment to enhance its stability