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Annu Rev Pharmacol Toxicol 44:32547, PMID: 14744249 Holmgren A, Lu J (2010) Thioredoxin and thioredoxin reductase: current research with special reference to human disease

Ravn-Haren G, Olsen A, Tjonneland A, Dragsted LO, Nexo BA, Wallin H, Overvad K, Raaschou-Nielsen O, Vogel U

If the issue lies with absorption, B12 shots or IV infusions are an effective alternative to oral supplements because they are administered via injection or intravenously, meaning they do not need to be absorbed through the digestive process

Laxatives are commonly used to treat constipation alone [17], and a systematic review indicates that use of laxation in constipation can attenuate abdominal pain [107], possibly by eliminating excessive stool and gases in the colon

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