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GGT is an heterodimeric glycoprotein located on the external plasma membrane of specific cells present in kidney tubules, biliary epithelium and brain capillaries where it hydrolyses GSH into glutamic acid and cysteinyl-glycine
It would be beneficial if compound 102 can inhibit Hv1 at the same time while activating GPX4, as both lead to the reduction of ROS and neuroprotective function
The development of PA often happens over a long period of time, so symptoms can often gradually worsen and become easily overlooked as the patient grows increasingly used to experiencing them
In this review, detailed information on drug-induced kidney injury mechanisms and available in vitro models to predict this with relevant translational biomarkers will be discussed, with an emphasis on novel developments in the field of microphysiological systems that meet the requirements of the 3Rs (replacement, reduction, refinement) of animal experiments for drug safety screenings
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