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In the early 1990s, it was discovered that the activity of the 20S proteasome is not restricted to complete degradation of its protein substrates, but that the complex can cleave at specific sites to generate functional cleavage products (Fan and Maniatis, 1991)

DOI Photodegradation of cobalamins and the relative stability of the cobalamin forms

J.PatassiniS.BegleyP.WaldvogelH