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We next further investigated whether the observed bell-shaped profile induced by high concentrations of dimeric macrocycles (3,000 nM) or HGF (30 nM) might be due to off-target inhibition of constitutively activated RTKs, which could potentially transactivate Met phosphorylation

Activation of p21WAF1/Cip1 expression by a temperature-sensitive mutant of human p53 does not lead to apoptosis

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