Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
15,16 On the other hand, TRX reductase (TRXR) utilizes NADPH as an electron donor to maintain the reduced form of TRX, which contributes to scavenge H 2 O 2 and reduce ribonucleotide reductase (RNR) for DNA synthesis
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population indicate a negative correlation between serum BL levels and PD incidence, with maximal protective effects observed at 10.84 mol/L (Su et al., 2024)
Lipid peroxidation products, such as 4-HNE and MDA, activate the p53 pathway, inhibit Bcl-2 (an anti-apoptotic protein), activate Bax (a pro-apoptotic protein), increase mitochondrial membrane permeability, release cytochrome c, and initiate the caspase cascade, ultimately leading to cell death ( Moreover, lipid peroxidation is closely associated with necrotic cell death