Topiramate has been shown to be an effective and well-tolerated prophylactic medication for the treatment of migraine ( Therefore, this review elucidates the etiology, inducements, pathogenesis and treatment modalities of migraine, the clinical evidence that migraine is associated with oxidative stress and neurogenic inflammation, as well as the experimental evidence of antioxidant and anti-inflammatory effects of topiramate, which is of great significance for further research and exploration of the possible mechanisms of topiramate in the treatment of migraine by modulating oxidative stress and neurogenic inflammatory pathways
The anti-inflammatory effects resulting from using resveratrol can be seen in the reduction of increased levels of interleukin and TNF in obese mice (153) and reduced OxS markers like glycated albumin levels in serum and 8-hydroxyguanosine in urine in stroke-prone spontaneously hypersensitive rats (154)
[7] GSH replacement, whether by mouth or combined with intravenous supplementation, is safe and well tolerated
Zi T, Liu YN, Zhang YS, Wang ZL, Wang ZX, Zhan S, et al
Clean the skin with alcohol, let it dry, pinch a fold of skin, insert the needle, inject slowly, withdraw, and press for a few seconds
