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Beyond mediating outer mitochondrial membrane fusion, Mfn1/2 participates in mitophagy regulation, mitochondrial cristae remodeling, and facilitates stress-associated unfolded protein response (UPR) (Hu et al., 2019

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357,361,371,372,373 Consistently, amygdalar axonal projections and neuronal activation are defective in Tbr1(+/) mice, but these defects are ameliorated by infusion of an NMDA receptor agonist (D-cycloserine)

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Injured tissue heals faster when it has an adequate blood supply delivering oxygen and nutrients