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Spirulina compounds show hypoglycemic activity and intestinal flora regulation in type 2 diabetes mellitus mice

doi: 10.1677/joe.0.1380327

Although a gold standard in exogenous substances behavior studies, Caco-2 cell monolayers exhibit certain limitations such as a much higher transepithelial electrical resistance (TEER, up to 500 cm 2 ) compared to the human intestine (1269 cm 2 ), overestimated P-gp-mediated efflux and low paracellular permeability, a lack of metabolic mucus and enzymes at their apical side, which limits the relevance of the Caco-2 cell line in metabolism studies under standard culture conditions (Thummel, 2007)

Tones and refines appearance of pores

Therefore, the use of p53-inhibitors for resistance epilepsy should be revised