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In some embodiments, the otic formulation or composition comprises between about 0.1% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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In later stages, chronic A exposure or inflammation may induce tolerance, reducing cytokine release and promoting repair, though this response can be maladaptive or insufficient

Unlike many peptides that degrade rapidly in biological fluids, this sequence demonstrates remarkable resistance to enzymatic breakdown, a property that the arginate salt form enhances even further

This doesnt necessarily mean the compound is unsafemany natural substances used for centuries lack extensive clinical trialsbut it does mean were working with incomplete data regarding human-specific effects, optimal dosing, long-term safety, and potential interactions