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the multifunctional growth factor hepatocyte growth factor (HGF) and its receptor Met are important mediators for mitogenesis, motogenesis, and morphogenesis in a wide range of cell types including epithelial, endothelial, and hematopoietic cells, neurons, melanocytes, and hepatocytes

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At the regulatory level, SIRT1 expression is influenced by transcriptional, epigenetic, post-transcriptional, and metabolic mechanisms

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J.2002Novel protein modification by kynurenine in human lenses.J Biol Chem.27748674873