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Previously it has been reported that curcumin as an anti-oxidant reduce gene and protein expression of KIM-1 and NGAL and alleviate oxidative toxic stress in the kidney tissue of type 1 diabetes rats [17]

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Blood 105 (3), 978985

However, long-lasting presence and accumulation of free radicals in the tissues restricts the effectiveness of the defense mechanisms and triggers uneven cellular responses associated with skin disorders, photosensitivity, and malignancies [35]