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Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohns disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial

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Nonetheless, induced differentiation of CD27 + IgD + unswitched memory B cells into D27 hi CD38 hi plasmablasts is accompanied by activation of mTORC1 ( Mitochondrial dysfunction in innate immune cells Neutrophils and plasmacytoid dendritic cells (pDCs) produce IFN- under the stimulation of nucleic acidprotein immune complexes (72), and NLRP3 signaling pathway ( The formation of neutrophil extracellular traps (NETs), which are extrusions of genomic DNA and chromatin to kill invading pathogens (73)

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