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Hydralazine prevents endothelial dysfunction, but not the increase in superoxide production in nitric oxide-deficient hypertension

The inclusion criteria included publications published in the previous decade, and the search approach was iterative, with continual refinement based on the identified literature until a thorough selection of relevant studies was obtained

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PLB has been shown to exert its anti-inflammatory and antioxidant effects by inhibiting signaling pathways such as PI3K/Akt/mTOR and nuclear factor-kappaB [34, 35]

Anal Biochem 74:214226 Jaworek J, Leja-Szpak A, Bonior J, Nawrot K, Tomaszewska R, Stachura J, Sendur R, Pawlik W, Brzozowski T, Konturek SJ (2003) Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion