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People with hormone-sensitive or autoimmune conditions Some ingredients may influence hormone activity or immune function, which could worsen conditions like endometriosis, uterine fibroids, or certain cancers, as well as autoimmune disorders such as lupus or rheumatoid arthritis.33 People who are pregnant, breastfeeding, or trying to conceive People taking medications that affect serotonin levels People with unexplained or severe symptoms Hormone-related symptoms like fatigue, irregular periods, or mood changes can sometimes be linked to underlying medical conditions

The main characteristics of all participants are presented in Supplementary Table S1

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